Featured Publications
Poor prognosis among radiation associated bladder cancer is defined by clinicogenomic features.
Wijetunga NA*, Gessner KH*, Kanchi K, Moore JA, Fleischmann Z, Jin DX, Frampton GM, Sturdivant M, Repka M, Sud S, Corcoran DL, Galsky MD, Milowsky MI, Wobker SE, Kim WY, Rose TL, Damrauer JS. Poor prognosis among radiation associated bladder cancer is defined by clinicogenomic features. Cancer Res Commun. 2024 Aug 8. doi: 10.1158/2767-9764.CRC-24-0352. Epub ahead of print. PMID: 39113632.; *Co-first authors.
PBRM1 inactivation promotes upregulation of human endogenous retroviruses in a HIF-dependent manner.
Zhou M, Leung JY, Gessner KH, Hepperla AJ, Simon JM, Davis IJ, Kim WY. “PBRM1 inactivation promotes upregulation of human endogenous retroviruses in a HIF-dependent manner.” Cancer Immunol Res. 2022 Jan 10. PMID: 35013001.
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation
Hacker KE*, Fahey CC*, Shinsky SA, Chang YJ, DiFiore JV, Jha DK, Vo AH, Shavit JA, Davis IJ, Strahl BS, Rathmell WK. “Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation. J Biol Chem. 2016 Sep 30;291(40):21283-21295. PMID: 27528607 *Co-first author.
The somatic genomic landscape of chromophobe renal cell carcinoma
Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA; Cancer Genome Atlas Research Network, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ. “The somatic genomic landscape of chromophobe renal cell carcinoma.” Cancer Cell. 2014 Sep 8;26(3):319-30.
Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects.
Simon JM*, Hacker KE*, Singh D, Brannon AR, Parker JS, Weiser M, Ho TH, Kuan PF, Jonasch E, Furey TS, Prins J, Lieb JD, Rathmell WK, and Davis IJ. “Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects.” Genome Research. 2014 Feb;24(2):241-50. PMID 24158655. *Co-first author.